To cause someone to feel sad.

दुखी करना

English Usage: The news of his departure was saddening for everyone.

Hindi Usage: उसकी Departure की खबर सबके लिए दुखदायी थी।

In a way that causes great grief or anguish; severely.

अत्यंत दुखदायी तरीके से

English Usage: She was grievously mistaken about his intentions.

Hindi Usage: वह उसकी मंशाओं के बारे में अत्यंत दुखदायी तरीके से गलत थी।