One who kills or destroys something

A person who excels at a particular activity (often used in slang)

विशेषज्ञ

English Usage: She's a real slayer on the basketball court.

Hindi Usage: वह बास्केटबॉल कोर्ट पर सचमुच विशेषज्ञ है।

To kill violently

To impress greatly (slang usage)

विशाल प्रभाव डालना

English Usage: Her performance really slayed the audience.

Hindi Usage: उसका प्रदर्शन वास्तव में दर्शकों पर विशाल प्रभाव डाल गया।